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Image Search Results
Journal: The Journal of Neuroscience
Article Title: Developmental Changes in Structural and Functional Properties of Hippocampal AMPARs Parallels the Emergence of Deliberative Spatial Navigation in Juvenile Rats
doi: 10.1523/JNEUROSCI.4827-12.2013
Figure Lengend Snippet: Model illustrating the relationships among AMPAR composition, AMPAR response duration, postsynaptic excitability, plasticity induction threshold, and spatial behavior across age groups and with CX614. CX614 has a lower EC50 for AMPARs containing GluA1 (Arai et al., 2000), the predominant subunit expressed at P17–P19, and produces pronounced effects on postsynaptic excitability and synaptic plasticity, which may act together or separately to affect spontaneous alternation. Compared with P17–P19, application of CX614 or increasing age (P22–P24) produce very similar changes in electrophysiological parameters and spatial navigation.
Article Snippet: To determine whether excitatory synaptic function limited hippocampal engagement at the end of the third postnatal week, we delivered positive modulators of
Techniques: